“Corrupting if you think you cannot dodge bombs/ you gonna get poked down eventually, Doran + 2 pots if you are decent at dodging skills / want to survive the burst easier / want to deal a bigger spike of damage if you can hit your W).
It is not a difficult matchup in terms of surviving. It is not easy to kill a decent Zilean as he will just E himself any time you want to W, so your main source of damage is Q while he E's himself and WE after that is over. Beware of his ult. You can push early much faster than him and you can roam better. He is a threat to you only if he comes close to E you and double Q to setup a jungler gank. Call your jungler, they should have no chance 2vs2 if you use your skills properly pre 6. Post 6 don't get baited by his ult for no reason.”
“dodge his skillshots and hard engage on him. He's going to play extremely safe and use his ult exactly when he's going to die. just watch how he's playing and you'll win. ”
“Not a lot of people play Zilean mid but he can be killed multiple times during laning phase if you hit your chains. Reason being is, he can only choose to speed up or double bomb, most will choose to speed up so that they can dodge your chain. Again, this leaves them vulnerable and you're able to make multiple burst combo's on him. After level 6, try your best to use your chains to slowly kill him since he will ult to come back. If you kill him whilst he ults, rinse and repeat the combo's until you kill him.”
“He is fast and his ult is kinda a nuisance. Other than that he has one damage ability that can be played around with good positioning. You will find it hard to kill him if they know what they are doing but then you just scale. ”
“Same as Ekko, he can't ult when he is stunned, he is also very squishy so try to burst him before he can use his R. Other than that just dodge his time bombs and you will be fine.”
“Zilean is actually quite a strong mid pick imo. He excels at peeling for allies and stopping pick comps from working. Unlucky for him, Orianna ult can pick multiple targets at once. In laning, always try to trade with him, especially after he throws a double bomb since he has a decent cooldown on his W. Don't push into him too much because his stun coupled with his E slow makes for a free kill for any jungler nearby.
Recommend: Barrier and Dmg Build. If he is hitting a lot of Qs on you, banshee veil works. But i personally find high damage and one-shooting multiple targets is much more effective against his playstyle. ”
“try not to get hit by his Q, use his high cooldowns in early game and punish him for every mistake”
“As long as he doesn't hit a double bomb on you, you'll be fine during laning, the problem occurs when he hits 6. Since he denies your ult with hit ult. The only thing I can suggest is perhaps getting your jungler to gank you to get his ult down, the use your ult once his ult is on cooldown. ”
“Zilean's speed steroid makes him very hard to land a charm on, he also will be able to outperform you in teamfights with his high damage and resurrect. Luckily his two core items, ROA and GLP were removed so he should be a lot less common in the midlane. ”
“Zilean cannot R while stunned, so as long as you burst him really quickly and dodge his Q + W + Q combo, you will do fine.”