“Since her release, Neeko has been tuned down and her damage has mellowed out. She is everything Teemo is, but better. If you get rooted you are pretty much dead, so avoid being hit by her (Q) which will pulsate & splash multiple times and will be often comboed when she has you rooted. She will set off your (R) with her (W) which is annoying as hell. Don't show her where you've been placing shrooms as they do this in bushes, from lane and the corners of the walls setting them off prematurely. It's overall an okay match-up as long you simply, learn to dodge her combos or avoid them all together.
“TL;DR - EVEN MATCHUP IN HER FAVOUR IF SHE BUILDS AP. DIFFICULT MATCHUP IF SHE BUILDS AD. PHASE RUSH IF CONFIDENT. CONQUEROR IF YOU KNOW ULL NEED THE EXTRA DAMAGE. DSHIELD WITH SECOND WIND AND UNFLINCHING ARE MANDATORY. IF YOU ARE TAKING CONQUEROR, TAKE TENACITY. IF SHE IS BUILDING AP, BUILD MERCS. IF SHE IS BUILDING AD, BUILD TABIS. PLAY PATIENTLY. WAIT FOR HER TO MISPOSITION. THEN PULL HER IN AND RUN HER DOWN. DON’T STAND CLOSE TO HER. GIVE UP CS IF NEEDED. DON’T STAND TOO CLOSE TO YOUR OWN MINIONS. DON’T GET HIT BY HER STUN. DON’T LET HER HIT YOU WITH HER EMPOWERED AUTO.
The Neeko matchup is very difficult to deal with for an inexperienced Darius. Her abilities are difficult to dodge as her stun gets faster when it passes through minions. The hitbox on it is very tricky to dodge, as it will not look like it hit you even though it did sometimes. Up against Neeko, you really need to play carefully. Once you kill her once, you will snowball really hard to the point where she really can’t do anything to you but up until that point, you simply need to be patient. Neeko’s early damage is INSANE. Don’t even try to trade with her level 1. Level 2 might work once you have your E but I’d still recommend being patient until level 3, as at that point you will have enough CC and slows to run her down. The good part is that if you hit her with an ability before she makes a clone of herself, your bleed stacks will be visible on the actual Neeko. Not to mention how your Q heals you when you hit Neeko’s clone with it. Start Dshield along with Second Wind and Unflinching. I’d recommend Phase Rush, as a lot of Neeko’s will be taking Glacial Augment which makes getting to her tricky at times but Conqueror works very well in this lane, as you sometimes need the damage to punch through her shield. Not to mention how by taking Precision into Resolve, you should be able to run max Tenacity which helps against Neeko. In this vain, an early Merc boots help against her a lot if she is going AP. AP Neeko does a LOT more poke damage which makes getting caught by her stun much more punishing. AD Neeko on the other hand is a different matter. AD Neeko with PTA is going to be able to take half of your HP bar away in SECONDS early on. DO NOT let her get her empowered auto attacks off on you. AD Neeko’s abilities and ultimate are quite terrible but her damage can be very surprising. If the Neeko builds AD, you’d better have packed tenacity in runes because you are going to NEED Ninja Tabi. Be patient. AD Neeko is still beatable. Just try to remain healthy throughout the lane and wait for the perfect opportunity. An AD Neeko, once behind, is going to do much less in teamfights than an AP Neeko who is behind.”
“Tons of damage. Will likely slap you and won't let you get into fling range unless she's a bad player. Neeko will absolutely shut down any attempt at doing anything, extremely oppressive lane.”
“Neeko can potentially be a very annoying matchup. Dshield with Second Wind makes life a lot easier. She is very easy to combo and burst down if you can land your abilities. Her abilities are just so "uncounterplayable", in that her animations are just really fucked up. You actually can't tell what she is gonna do sometimes which really screws with your dodging. Not to mention how her abilities' hitboxes are just completely screwed. Overall, make sure she does not land her root. She can shoot it thru minions an it becomes faster so if you can, make sure there is a fair bit of distance so you can dodge. If you get hit, you will get chunked down. Thankfully, you can fight back if she misses and win, AND with your ultimate, you should easily take her down. Protobelt rush is quite good here.”
“This matchup is simply annoying, try your best to dodge her E since it's quite a long root and allows her to follow up with the rest of her combo, also remember If Tangle-Barbs (her E) hits at least one enemy, it grows in size and speed, and the root duration is increased. So it can be smart to play outside of your minion wave and not give her those free angles, if it's AP neeko which most are now once you have some magic resist this matchup gets a lot easier, you can also save your E to get out of her R since she stops when she goes up in the air and you have a bit of time to get out of the circle.”
“AD or AP Neeko are both extreme threats as they can out-kite you and out-DPS you. Avoid her Tangle-Barbs(E) and you can trade evenly. Get out of Pop Blossom(R) to prevent damage and snaring. Avoid wasting resources on her Shapesplitter(W). (Recommended Items: Mercury's Treads, Rylai's Scepter, Force of Nature) (Outscaling Edge: Singed) (Sustained 1v1 Trades: Neeko)”
“Neeko is quite an annoying champion to face. She will probably try to rush level 2 for her burst damage so keep that in mind. I'd suggest you wait for level 3 until you have Windwall before you tarde with her.
Do short, 2-3 sec. trades and wait for your Windwall to come off cooldown. If you manage to avoid her snare, then you can go in and trade.
I'd suggest to buy hexdrinker after PD because her ult damage is quite big, you can't escape it (unless you have flash) and you can't stop it.
You can actually use your ult on her while she becomes invisible for a split sec. and separates in 2.”
“Don't stand in the after ticks of their abilities and you'll be fine. Abuse them when their clone is on cooldown, or just play safe till level 6, and when they want to all in you, just ult their R so you don't get stunned then finish them off. Stridebreaker is useful in this matchup but you can go Trinity for the burst. Take Force of Nature 2nd or 3rd item.”
“Dorans shield, Second wind and get spectre's cowl and you should be able to beat her from there on.”
“Annyoing opponent. Get fast Tiamat to outpush waves and Mercury for laning/fighting Neeko . ”